Orange juice–derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease12345
Identifieur interne : 000516 ( Main/Exploration ); précédent : 000515; suivant : 000517Orange juice–derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease12345
Auteurs : Manuel Y. Sch R ; Peter J. Curtis ; Sara Hazim ; Luisa M. Ostertag ; Colin D. Kay ; John F. Potter ; Aedín CassidySource :
- The American Journal of Clinical Nutrition [ 0002-9165 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Beverages (analysis), Biomarkers (blood), Cardiovascular Diseases (prevention & control), Cardiovascular System (drug effects), Cardiovascular System (metabolism), Chromatography, High Pressure Liquid, Citrus sinensis (chemistry), Cross-Over Studies, Dietary Supplements, Hesperidin (administration & dosage), Hesperidin (blood), Humans, Male, Middle Aged, Phenols (administration & dosage), Phenols (blood), Risk Factors.
- MESH :
- chemical , administration & dosage : Hesperidin, Phenols.
- chemical , blood : Biomarkers, Hesperidin, Phenols.
- analysis : Beverages.
- chemistry : Citrus sinensis.
- drug effects : Cardiovascular System.
- metabolism : Cardiovascular System.
- prevention & control : Cardiovascular Diseases.
- Aged, Chromatography, High Pressure Liquid, Cross-Over Studies, Dietary Supplements, Humans, Male, Middle Aged, Risk Factors.
Abstract
Url:
DOI: 10.3945/ajcn.114.104364
PubMed: 25788001
PubMed Central: 4409690
Affiliations:
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Orange juice–derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease<xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>2</sup></xref><xref ref-type="author-notes" rid="fn2"><sup>3</sup></xref><xref ref-type="author-notes" rid="fn3"><sup>4</sup></xref><xref ref-type="corresp" rid="cor1"><sup>5</sup></xref></title><author><name sortKey="Sch R, Manuel Y" sort="Sch R, Manuel Y" uniqKey="Sch R M" first="Manuel Y" last="Sch R">Manuel Y. Sch R</name></author><author><name sortKey="Curtis, Peter J" sort="Curtis, Peter J" uniqKey="Curtis P" first="Peter J" last="Curtis">Peter J. Curtis</name></author><author><name sortKey="Hazim, Sara" sort="Hazim, Sara" uniqKey="Hazim S" first="Sara" last="Hazim">Sara Hazim</name></author><author><name sortKey="Ostertag, Luisa M" sort="Ostertag, Luisa M" uniqKey="Ostertag L" first="Luisa M" last="Ostertag">Luisa M. Ostertag</name></author><author><name sortKey="Kay, Colin D" sort="Kay, Colin D" uniqKey="Kay C" first="Colin D" last="Kay">Colin D. Kay</name></author><author><name sortKey="Potter, John F" sort="Potter, John F" uniqKey="Potter J" first="John F" last="Potter">John F. Potter</name></author><author><name sortKey="Cassidy, Aedin" sort="Cassidy, Aedin" uniqKey="Cassidy A" first="Aedín" last="Cassidy">Aedín Cassidy</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25788001</idno><idno type="pmc">4409690</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409690</idno><idno type="RBID">PMC:4409690</idno><idno type="doi">10.3945/ajcn.114.104364</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000029</idno><idno type="wicri:Area/Pmc/Curation">000029</idno><idno type="wicri:Area/Pmc/Checkpoint">000404</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000181</idno><idno type="wicri:Area/PubMed/Curation">000181</idno><idno type="wicri:Area/PubMed/Checkpoint">000181</idno><idno type="wicri:Area/Ncbi/Merge">001A44</idno><idno type="wicri:Area/Ncbi/Curation">001A44</idno><idno type="wicri:Area/Ncbi/Checkpoint">001A44</idno><idno type="wicri:doubleKey">0002-9165:2015:Sch R M:orange:juice:derived</idno><idno type="wicri:Area/Main/Merge">000516</idno><idno type="wicri:Area/Main/Curation">000516</idno><idno type="wicri:Area/Main/Exploration">000516</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Orange juice–derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebo-controlled, crossover trial in men at moderate risk of cardiovascular disease<xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>2</sup></xref><xref ref-type="author-notes" rid="fn2"><sup>3</sup></xref><xref ref-type="author-notes" rid="fn3"><sup>4</sup></xref><xref ref-type="corresp" rid="cor1"><sup>5</sup></xref></title><author><name sortKey="Sch R, Manuel Y" sort="Sch R, Manuel Y" uniqKey="Sch R M" first="Manuel Y" last="Sch R">Manuel Y. Sch R</name></author><author><name sortKey="Curtis, Peter J" sort="Curtis, Peter J" uniqKey="Curtis P" first="Peter J" last="Curtis">Peter J. Curtis</name></author><author><name sortKey="Hazim, Sara" sort="Hazim, Sara" uniqKey="Hazim S" first="Sara" last="Hazim">Sara Hazim</name></author><author><name sortKey="Ostertag, Luisa M" sort="Ostertag, Luisa M" uniqKey="Ostertag L" first="Luisa M" last="Ostertag">Luisa M. Ostertag</name></author><author><name sortKey="Kay, Colin D" sort="Kay, Colin D" uniqKey="Kay C" first="Colin D" last="Kay">Colin D. Kay</name></author><author><name sortKey="Potter, John F" sort="Potter, John F" uniqKey="Potter J" first="John F" last="Potter">John F. Potter</name></author><author><name sortKey="Cassidy, Aedin" sort="Cassidy, Aedin" uniqKey="Cassidy A" first="Aedín" last="Cassidy">Aedín Cassidy</name></author></analytic><series><title level="j">The American Journal of Clinical Nutrition</title><idno type="ISSN">0002-9165</idno><idno type="eISSN">1938-3207</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Beverages (analysis)</term><term>Biomarkers (blood)</term><term>Cardiovascular Diseases (prevention & control)</term><term>Cardiovascular System (drug effects)</term><term>Cardiovascular System (metabolism)</term><term>Chromatography, High Pressure Liquid</term><term>Citrus sinensis (chemistry)</term><term>Cross-Over Studies</term><term>Dietary Supplements</term><term>Hesperidin (administration & dosage)</term><term>Hesperidin (blood)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Phenols (administration & dosage)</term><term>Phenols (blood)</term><term>Risk Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Hesperidin</term><term>Phenols</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Hesperidin</term><term>Phenols</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Beverages</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Citrus sinensis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cardiovascular System</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cardiovascular System</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Cardiovascular Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Chromatography, High Pressure Liquid</term><term>Cross-Over Studies</term><term>Dietary Supplements</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> Epidemiologic data suggest inverse associations between citrus flavanone intake and cardiovascular disease (CVD) risk. However, insufficient randomized controlled trial data limit our understanding of the mechanisms by which flavanones and their metabolites potentially reduce cardiovascular risk factors.</p><p><bold>Objective:</bold> We examined the effects of orange juice or a dose-matched hesperidin supplement on plasma concentrations of established and novel flavanone metabolites and their effects on cardiovascular risk biomarkers in men at moderate CVD risk.</p><p><bold>Design:</bold> In an acute, randomized, placebo-controlled crossover trial, 16 fasted participants (aged 51–69 y) received orange juice or a hesperidin supplement (both providing 320 mg hesperidin) or control (all matched for sugar and vitamin C content). At baseline and 5 h postintake, endothelial function (primary outcome), blood pressure, arterial stiffness, cardiac autonomic function, platelet activation, and NADPH oxidase gene expression and plasma flavanone metabolites were assessed. Before each intervention, a diet low in flavonoids, nitrate/nitrite, alcohol, and caffeine was followed, and a standardized low-flavonoid evening meal was consumed.</p><p><bold>Results:</bold> Orange juice intake significantly elevated mean ± SEM plasma concentrations of 8 flavanone (1.75 ± 0.35 μmol/L, <italic>P</italic> < 0.0001) and 15 phenolic (13.27 ± 2.22 μmol/L, <italic>P</italic> < 0.0001) metabolites compared with control at 5 h postconsumption. Despite increased plasma flavanone and phenolic metabolite concentrations, cardiovascular risk biomarkers were unaltered. After hesperidin supplement intake, flavanone metabolites were not different from the control, suggesting altered absorption/metabolism compared with the orange juice matrix.</p><p><bold>Conclusions:</bold> After single-dose flavanone intake within orange juice, circulating flavanone and phenolic metabolites collectively reached a concentration of 15.20 ± 2.15 μmol/L, but no effects were observed on cardiovascular risk biomarkers. Longer-duration randomized controlled trials are required to examine previous associations between higher flavanone intakes and improved cardiovascular health and to ascertain the relative importance of food matrix and flavanone-derived phenolic metabolites. 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K">K Goetschalckx</name></author><author><name sortKey="Thomaes, T" uniqKey="Thomaes T">T Thomaes</name></author><author><name sortKey="Verhamme, P" uniqKey="Verhamme P">P Verhamme</name></author><author><name sortKey="Vanhees, L" uniqKey="Vanhees L">L Vanhees</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lind, L" uniqKey="Lind L">L Lind</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fuchs, D" uniqKey="Fuchs D">D Fuchs</name></author><author><name sortKey="De Graaf, Y" uniqKey="De Graaf Y">Y de Graaf</name></author><author><name sortKey="Van Kerckhoven, R" uniqKey="Van Kerckhoven R">R van Kerckhoven</name></author><author><name sortKey="Draijer, R" uniqKey="Draijer R">R Draijer</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Cassidy, Aedin" sort="Cassidy, Aedin" uniqKey="Cassidy A" first="Aedín" last="Cassidy">Aedín Cassidy</name><name sortKey="Curtis, Peter J" sort="Curtis, Peter J" uniqKey="Curtis P" first="Peter J" last="Curtis">Peter J. Curtis</name><name sortKey="Hazim, Sara" sort="Hazim, Sara" uniqKey="Hazim S" first="Sara" last="Hazim">Sara Hazim</name><name sortKey="Kay, Colin D" sort="Kay, Colin D" uniqKey="Kay C" first="Colin D" last="Kay">Colin D. Kay</name><name sortKey="Ostertag, Luisa M" sort="Ostertag, Luisa M" uniqKey="Ostertag L" first="Luisa M" last="Ostertag">Luisa M. Ostertag</name><name sortKey="Potter, John F" sort="Potter, John F" uniqKey="Potter J" first="John F" last="Potter">John F. Potter</name><name sortKey="Sch R, Manuel Y" sort="Sch R, Manuel Y" uniqKey="Sch R M" first="Manuel Y" last="Sch R">Manuel Y. Sch R</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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